Author’s response to reviews Title: Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma. Authors:
نویسندگان
چکیده
We thank reviewer 1 for this feedback. An additional paragraph has been included in the introduction describing previous studies that have reported high levels of members of the NER pathway in cancer, in particular ERCC1. We have previously published a review article on this topic: Bowden NA. (2014) Nucleotide excision repair: why is it not used to predict response to platinum-based chemotherapy? Cancer Letters 346(2). When writing this review article it became apparent that vast majority of previous studies investigating NER in cancer have focused on ERCC1. The focus of the manuscript under review is the global genome repair branch of NER, in particular XPC, a different component of the NER pathway with a different function to ERCC1. Therefore, we have explained this in more detail. The following has been added to page 3:
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